I would just ignore the drones since they aren’t a big threat anyway. When you shoot them, beware the boss will spawn new ones and the old drones turn into seeker mines to hunt you down and explode near you. You can either ignore them or shoot them (they have very little health and are quickly destroyed). It will use mostly laser attacks but also has two little drones that can attack you. This is a flying boss and one of the harder foes in the game. The Overture Devil Breaker also does a good deal of damage. You can also double jump in the air and do air attacks behind his back. Whenever he moves his arms press + / to evade immediately.
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If you want to do it the “fun” way you can lock on to the boss and melee him from behind. Slow but effective! Hold / to charge up 3 destructive shots, it does more damage per second than shooting quickly. Again, you can do it the cheesy way and simply use the revolver from afar to minimize risk. The Goliath has a ton of health but it’s relatively slow. When the arms move it’s about to launch an attack so get away quickly. Alternatively, get in with melee attacks when its arms aren’t about to attack. Just shoot it from afar with the revolver if you want to play it totally safe. It only attacks with its tentacles but can also spawn single enemies. If you finish it you get the secret Prologue ending. If your health depletes only once you get a cutscene and the fight fails. On human you can beat him in 2 rounds, on Devil Hunter in 3-4 rounds. Be sure to get close to him just before destroying the crystal to not waste any attack time.
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Beware he repairs the crystal and you only have a few seconds to attack. When the crystal is destroyed you can attack the boss. Just keep walking sideways at all times and shoot the crystal from afar. He uses blue spheres that slow you, red lava balls that hurt you, a laser beam that whips across the whole area, and energy beams that come from the floor. You will have to evade the boss attacks quite perfectly. On first try this can be pretty tough so you may want to try it later after upgrading some skills and getting more health.
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First you must destroy the crystal to hurt him. The Prologue boss is guarded by a red crystal.